Methods. A literature search using the databases Medscape, Pubmed, UpToDate and
EBSCO from 1945 to 2015. Results and Conclusions. Genetic predisposition/hereditary …

The family of aldehyde dehydrogenases (ALDHs) contains 19 isozymes and is involved in
the oxidation of endogenous and exogenous aldehydes to carboxylic acids, which …

To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …

Breast cancer is the second-most common cancer and second-leading cause of cancer
mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in …

Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer, and it
has the highest mortality rate. The increasing drug resistance of metastatic ccRCC has …

Epidemiological studies implicate excess ethanol ingestion as a risk factor for several
cancers and support the concept of a synergistic effect of chronic alcohol consumption and …

Abstract Aims Circular RNAs (circRNAs) are endogenous covalently closed non-coding
RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in …

A significant need for reliable and accurate cancer diagnostics and prognosis compels the
search for novel biomarkers that would be able to discriminate between indolent and …

Abstract ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in
folate metabolism commonly downregulated in human cancers. One of the mechanisms of …

Older age is one of the main risk factors for cancer development. The incidence of prostate
cancer, as a multifactorial disease, also depends upon demographic factors, race, and …