Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis

VM Holers, KM Demoruelle, JH Buckner… - Nature Reviews …, 2024 - nature.com
Rheumatoid arthritis (RA) is a potentially devastating autoimmune disease. The great
majority of patients with RA are seropositive for anti-citrullinated protein antibodies (ACPAs) …

MAIT cells: Conserved watchers on the wall

L Germain, P Veloso, O Lantz, F Legoux - Journal of Experimental …, 2025 - rupress.org
MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and
intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element …

Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods

T Branck, Z Hu, WA Nickols, AM Walsh… - The ISME …, 2024 - academic.oup.com
The gut microbiome of companion animals is relatively underexplored, despite its relevance
to animal health, pet owner health, and basic microbial community biology. Here, we provide …

Microbiota-bone axis in ageing-related bone diseases

L Fu, P Zhang, Y Wang, X Liu - Frontiers in Endocrinology, 2024 - frontiersin.org
Bone homeostasis in physiology depends on the balance between bone formation and
resorption, and in pathology, this homeostasis is susceptible to disruption by different …

The gut microbiome in systemic lupus erythematosus: lessons from rheumatic fever

GJ Silverman, DF Azzouz, N Gisch… - Nature Reviews …, 2024 - nature.com
For more than a century, certain bacterial infections that can breach the skin and mucosal
barriers have been implicated as common triggers of autoimmune syndromes, especially …

Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory …

MS Kragsnaes, JRB Jensen, AC Nilsson, MI Malik… - RMD open, 2024 - rmdopen.bmj.com
Objectives The gut microbiota can mediate both pro and anti-inflammatory responses. In
patients with psoriatic arthritis (PsA), we investigated the impact of faecal microbiota …

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗ 27 confers risk for spondyloarthritis

EM Brown, PNU Nguyen, RJ Xavier - Cell Chemical Biology, 2025 - cell.com
The strong association of the human leukocyte antigen B∗ 27 alleles (HLA-B∗ 27) with
spondyloarthritis and related rheumatic conditions has long fascinated researchers, yet the …

The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses

HJ Huang, C Liu, XW Sun, RQ Wei, LW Liu, HY Chen… - Imeta, 2024 - Wiley Online Library
Gut microbiota dysbiosis has been implicated in rheumatoid arthritis (RA) and influences
disease progression. Although molecular and culture‐independent studies revealed RA …

Microbiome research in autoimmune and immune-mediated inflammatory diseases: lessons, advances and unmet needs

JU Scher, R Nayak, JC Clemente - Annals of the rheumatic diseases, 2025 - Elsevier
The increasing prevalence of autoimmune and immune-mediated diseases (AIMDs)
underscores the need to understand environmental factors that contribute to their …

The role of the gastrointestinal microbiome on rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and reactive arthritis: A systematic review

BCK Ng, M Lassere - Seminars in Arthritis and Rheumatism, 2025 - Elsevier
Background There is an increasing body of literature observing a state of dysbiosis in the gut
microbiome in different autoimmune conditions including inflammatory arthritis. It is unknown …