Update on in vitro cytotoxicity assays for drug development
Background: in vitro cytotoxicity testing provides a crucial means of ranking compounds for
consideration in drug discovery. The choice of using a particular viability or cytotoxicity …
consideration in drug discovery. The choice of using a particular viability or cytotoxicity …
[HTML][HTML] A review for cell-based screening methods in drug discovery
F Wei, S Wang, X Gou - Biophysics Reports, 2021 - ncbi.nlm.nih.gov
With the biological relevance of the whole cells, low cost compared with animal experiments,
a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics …
a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics …
[HTML][HTML] In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening
In vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a
convenient, costeffective, and predictive means of characterizing the toxic potential of new …
convenient, costeffective, and predictive means of characterizing the toxic potential of new …
[HTML][HTML] Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses
B Forbes, R O'Lone, PP Allen, A Cahn, C Clarke… - Advanced drug delivery …, 2014 - Elsevier
Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology
studies, typically being observed as an increase in number or a vacuolated …
studies, typically being observed as an increase in number or a vacuolated …
A multi-modality CMOS sensor array for cell-based assay and drug screening
In this paper, we present a fully integrated multi-modality CMOS cellular sensor array with
four sensing modalities to characterize different cell physiological responses, including …
four sensing modalities to characterize different cell physiological responses, including …
Bisindolylmaleimide Ligands Stabilize c-MYC G-Quadruplex DNA Structure and Downregulate Gene Expression
G-Quadruplex (G4) structures play a pivotal role in diverse biological functions, including
essential processes, such as telomere maintenance and gene regulation. G4 structures …
essential processes, such as telomere maintenance and gene regulation. G4 structures …
Targeting Parallel Topology of G-Quadruplex Structures by Indole-Fused Quindoline Scaffolds
Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has
emerged as an effective approach to develop anticancer drugs. Herein, we report the …
emerged as an effective approach to develop anticancer drugs. Herein, we report the …
Viability assessment following anticancer treatment requires single-cell visualization
R Mirzayans, B Andrais, D Murray - Cancers, 2018 - mdpi.com
A subset of cells within solid tumors become highly enlarged and enter a state of dormancy
(sustained proliferation arrest) in response to anticancer treatment. Although dormant cancer …
(sustained proliferation arrest) in response to anticancer treatment. Although dormant cancer …
Cell-based assays for assessing toxicity: a basic guide
R Parboosing, G Mzobe, L Chonco… - Medicinal …, 2017 - ingentaconnect.com
Assessment of toxicity is an important component of the drug discovery process. Cellbased
assays are a popular choice for assessing cytotoxicity. However, these assays are complex …
assays are a popular choice for assessing cytotoxicity. However, these assays are complex …
Essential oil with anticancer activity: An overview
An increased interest by consumers toward pharmacologically active plant-derived natural
products as alternatives to synthetic drugs has increased the attention of global scientists …
products as alternatives to synthetic drugs has increased the attention of global scientists …