In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective
organelles, has entered the research spotlight largely owing to the discovery of the protein …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and
other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical …

Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …

The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about
50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 …

The small GTP binding protein Rab7 has a role in the late endocytic pathway and lysosome
biogenesis. The role of mammalian Rab7 in autophagy is, however, unknown. We have …

Autophagy delivers cytoplasmic material and organelles to lysosomes for degradation. The
formation of autophagosomes is controlled by a specific set of autophagy genes called atg …

Lysosome‐associated membrane proteins 1 and 2 (LAMP‐1 and LAMP‐2) are delivered to
phagosomes during the maturation process. We used cells from LAMP‐deficient mice to …