Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

Colorectal cancer (CRC) is one of the most common malignant carcinomas. CRC is
characterized by asymptomatic onset, and most patients are already in the middle and …

Background & Aims Fecal microbiota transplantation (FMT) is an emerging treatment
modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy …

Over the past decade, colorectal cancer has reported a higher incidence in younger adults
and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation …

Immune checkpoint blockade (ICB) therapy potently revives T cell's response to cancer.
However, patients suffered with tumors that had inadequate infiltrated immune cells only …

Ulcerative colitis (UC) is a recurrent chronic inflammation of the colon with increasing
incidence and prevalence, which could increase the risk of colorectal cancer. It is urgent to …

Abstract Background Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in
colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME) …

The treatment outcomes of nanomedicines against colorectal cancer are severely restricted
by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and …

Targeting gut microbiota has shown promise to prevent experimental acute kidney injury
(AKI). However, this has not been studied in relation to accelerating recovery and preventing …

Introduction Dysbiosis of the gut microbiota is emerging as a pivotal factor in the
pathogenesis of colorectal cancer (CRC). Ginsenoside Rh4 (Rh4) is an active compound …