Decision-making in sensorimotor control

JP Gallivan, CS Chapman, DM Wolpert… - Nature Reviews …, 2018 - nature.com
Skilled sensorimotor interactions with the world result from a series of decision-making
processes that determine, on the basis of information extracted during the unfolding …

Multiregion neuronal activity: the forest and the trees

TA Machado, IV Kauvar, K Deisseroth - Nature Reviews Neuroscience, 2022 - nature.com
The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

Thalamic regulation of switching between cortical representations enables cognitive flexibility

RV Rikhye, A Gilra, MM Halassa - Nature neuroscience, 2018 - nature.com
Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …

The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

B DePasquale, D Sussillo, LF Abbott, MM Churchland - Neuron, 2023 - cell.com
Neural activity is often described in terms of population-level factors extracted from the
responses of many neurons. Factors provide a lower-dimensional description with the aim of …

Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making

MC Aoi, V Mante, JW Pillow - Nature neuroscience, 2020 - nature.com
Recent work has suggested that the prefrontal cortex (PFC) plays a key role in context-
dependent perceptual decision-making. In this study, we addressed that role using a new …

Neural latents benchmark'21: evaluating latent variable models of neural population activity

F Pei, J Ye, D Zoltowski, A Wu, RH Chowdhury… - arxiv preprint arxiv …, 2021 - arxiv.org
Advances in neural recording present increasing opportunities to study neural activity in
unprecedented detail. Latent variable models (LVMs) are promising tools for analyzing this …

Posterior parietal cortex plays a causal role in perceptual and categorical decisions

Y Zhou, DJ Freedman - Science, 2019 - science.org
Posterior parietal cortex (PPC) activity correlates with monkeys' decisions during visual
discrimination and categorization tasks. However, recent work has questioned whether …

Beyond trial-based paradigms: Continuous behavior, ongoing neural activity, and natural stimuli

A Huk, K Bonnen, BJ He - Journal of Neuroscience, 2018 - Soc Neuroscience
The vast majority of experiments examining perception and behavior are conducted using
experimental paradigms that adhere to a rigid trial structure: each trial consists of a brief and …

An integrative framework for sensory, motor, and cognitive functions of the posterior parietal cortex

DJ Freedman, G Ibos - Neuron, 2018 - cell.com
Throughout the history of modern neuroscience, the parietal cortex has been associated
with a wide array of sensory, motor, and cognitive functions. The use of non-human primates …

Differentiating between integration and non-integration strategies in perceptual decision making

GM Stine, A Zylberberg, J Ditterich, MN Shadlen - Elife, 2020 - elifesciences.org
Many tasks used to study decision-making encourage subjects to integrate evidence over
time. Such tasks are useful to understand how the brain operates on multiple samples of …