Recent advances in structural, biochemical, biophysical, and live cell imaging approaches
have furthered our understanding of the molecular mechanisms by which regulated …

A key question in understanding microtubule dynamics is how GTP hydrolysis leads to
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …

Multivalent biopolymers phase separate into membrane-less organelles (MLOs) which
exhibit liquid-like behavior. Here, we explore formation of prototypical MOs from multivalent …

Cell motility and actin homeostasis depend on the control of polarized growth of actin
filaments. Profilin, an abundant regulator of actin dynamics, supports filament assembly at …

In cells, a complex network of proteins regulates the dynamic growth of microtubules that is
essential for division and migration. In vitro approaches with purified components have so …

Membrane-active cytoskeletal elements, such as FtsZ, septin or actin, form filamentous
polymers able to induce and stabilize curvature on cellular membranes. In order to emulate …

Microtubule (MT) dynamic instability is fundamental to many cell functions, but its
mechanism remains poorly understood, in part because it is difficult to gain information …

Development of an energy-driven self-assembly process is a matter of interest for
understanding and mimicking diverse ranges of biological and environmental patterns in a …

Dynamic instability, in which abrupt transitions occur between growing and shrinking states,
is an intrinsic property of microtubules that is regulated by both mechanics and specialized …

Uncovering mechanisms that control the dynamics of microtubules is fundamental for our
understanding of multiple cellular processes such as chromosome separation and cell …