[HTML][HTML] The NLRP3 inflammasome as a target for sensorineural hearing loss

GE Gregory, KJ Munro, KN Couper… - Clinical …, 2023 - Elsevier
Sensorineural hearing loss is the most common type of hearing loss in adults and occurs
due to damage of the inner ear caused by a range of factors including ageing, excessive …

Targeting tumor physical microenvironment for improved radiotherapy

J Wang, Y Han, Y Li, F Zhang, M Cai, X Zhang… - Small …, 2022 - Wiley Online Library
Radiotherapy has led to important clinical advances; existing cancer radiotherapy resistance
is one remaining major challenge. Recently, biophysical cues in the tumor …

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits

M Datta, LE Via, V Dartois, DM Weiner… - Proceedings of the …, 2024 - pnas.org
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance
during tuberculosis (TB) infection. While most HDTs are designed and implemented for …

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

L Gu, Y Zhu, M Lee, A Nguyen, NT Ryu**… - Proceedings of the …, 2023 - pnas.org
Although viral hepatocellular carcinoma (HCC) is declining, nonviral HCC, which often is the
end stage of nonalcoholic or alcoholic steatohepatitis (NASH, ASH), is on an upward …

Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery

W Zhou, Y Jiang, Q Xu, L Chen, H Qiao… - Nature Biomedical …, 2023 - nature.com
In microneurosurgery, it is crucial to maintain the structural and functional integrity of the
nerve through continuous intraoperative identification of neural anatomy. To this end, here …

Potential molecular biomarkers of vestibular schwannoma growth: progress and prospects

Y Zhang, J Long, J Ren, X Huang, P Zhong… - Frontiers in …, 2021 - frontiersin.org
Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign
brain tumors stem from the Schwann cells of the eighth cranial nerve. Tumor growth is the …

Sporadic vestibular schwannoma size and location do not correlate with the severity of hearing loss at initial presentation

A Brown, S Early, S Vasilijic, KM Stankovic - Frontiers in oncology, 2022 - frontiersin.org
Vestibular schwannoma (VS) is a non-malignant intracranial neoplasm arising from the
vestibular branch of the 8th cranial nerve; sensorineural hearing loss (SNHL) is the most …

Probing the physical hallmarks of cancer

HT Nia, LL Munn, RK Jain - Nature Methods, 2025 - nature.com
The physical microenvironment plays a crucial role in tumor development, progression,
metastasis and treatment. Recently, we proposed four physical hallmarks of cancer, with …

Inhibiting AGTR1 reduces AML burden and protects the heart from cardiotoxicity in mouse models

Y Pan, C Wang, WX Zhou, Y Shi, XD Meng… - Science translational …, 2024 - science.org
Clinical treatment of acute myeloid leukemia (AML) largely relies on intensive
chemotherapy. However, the application of chemotherapy is often hindered by cardiotoxicity …

Immune profiling of secreted factors from human vestibular schwannoma cells and tumor‐associated macrophages

KM Stankovic, S Batts, DB Welling… - The …, 2024 - Wiley Online Library
Objectives This study compared the immune‐related secretory capacity of human vestibular
schwannoma (VS) and tumor‐assisted macrophages (TAMs) with their normal counterparts …