Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical
need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl …

The glycocalyx generally covers almost all cellular surfaces, where it participates in
mediating cell-surface interactions with the extracellular matrix as well as with intracellular …

Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …

Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is
responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and …

In this comprehensive meta-regression analysis encompassing 79 randomized controlled
trials, we observed that in populations assigned to a high sodium intake level exceeding 94 …

Deranged histone deacetylase (HDAC) activity causes uncontrolled proliferation,
inflammation, fibrosis, and organ damage. It is unclear whether deranged HDAC activity …

In this review, we first provide a brief overview of the nitric oxide synthase (NOS) isoforms
and biochemistry. This is followed by describing what is known about NOS-mediated blood …

Histone deacetylase (HDAC) enzymes regulate transcription through epigenetic
modification of chromatin structure, but their specific functions in the kidney remain elusive …

The collecting duct (CD) concentrates the urine, thereby maintaining body water volume and
plasma osmolality within a normal range. The endocrine hormone arginine vasopressin acts …

Genes for the epithelial sodium channel (ENaC) subunits are expressed in a circadian
manner, but whether this results in time-of-day differences in activity is not known. Recent …