Medicinal attributes of 1, 2, 3-triazoles: Current developments
Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …
activities. This framework can be readily obtained in good to excellent yields on the …
CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
Metal-catalyzed azide-alkyne “click” reactions: Mechanistic overview and recent trends
This review is focused on the mechanistic aspects and recent trends of the metal-catalyzed
azide-alkyne cycloaddition (MAAC) so-called “click” reactions with catalysts based on …
azide-alkyne cycloaddition (MAAC) so-called “click” reactions with catalysts based on …
Design, synthesis, anticancer evaluation, enzymatic assays, and a molecular modeling study of novel pyrazole–indole hybrids
The molecular hybridization concept has recently emerged as a powerful approach in drug
discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed …
discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed …
Application of triazoles in the structural modification of natural products
HY Guo, ZA Chen, QK Shen… - Journal of enzyme …, 2021 - Taylor & Francis
Nature products have been extensively used in the discovery and development of new
drugs, as the most important source of drugs. The triazole ring is one of main …
drugs, as the most important source of drugs. The triazole ring is one of main …
Recent progress in 1H-1, 2, 3-triazoles as potential antifungal agents
The need to overcome ever-increasing cases of antifungal resistance and circumvent side
effects and drug interactions related to currently available drugs has impelled the demand to …
effects and drug interactions related to currently available drugs has impelled the demand to …
New progress in azole compounds as antimicrobial agents
HZ Zhang, LL Gan, H Wang… - Mini reviews in medicinal …, 2017 - ingentaconnect.com
The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …
become a serious challenge for public health. More and more efforts have been directed to …
Indole-2-carboxylic acid derived mono and bis 1, 4-disubstituted 1, 2, 3-triazoles: Synthesis, characterization and evaluation of anticancer, antibacterial, and DNA …
S Narsimha, NS Kumar, BK Swamy, NV Reddy… - Bioorganic & medicinal …, 2016 - Elsevier
A series of new indole-2-carboxylic acid derived mono and bis 1, 4-disubstituted 1, 2, 3
triazoles (I 1–I 6 and I 7–I 12) were synthesized and screened for their anticancer (in vitro …
triazoles (I 1–I 6 and I 7–I 12) were synthesized and screened for their anticancer (in vitro …
[HTML][HTML] Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity
Z **ao, Y Gu, H Dong, B Liu, W **, J Li, P Ma… - European Journal of …, 2023 - Elsevier
Natural products play a key role in the history of human drug discovery, and especially for
the anticancer agents. Copper (I)-catalyzed alkyne-azide [3+ 2] cycloaddition (CuAAC) …
the anticancer agents. Copper (I)-catalyzed alkyne-azide [3+ 2] cycloaddition (CuAAC) …
Fe3O4@SiO2-PMA-Cu magnetic nanoparticles as a novel catalyst for green synthesis of β-thiol-1,4-disubstituted-1,2,3-triazoles
The magnetic nanoparticles of Fe3O4 were synthesized through a solid-state reaction of
hydrated iron (III) chloride, hydrated iron (II) chloride and NaOH, and then purified by …
hydrated iron (III) chloride, hydrated iron (II) chloride and NaOH, and then purified by …