Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Cancer is a major cause of death worldwide, with an increasing number of cases being
reported annually. The elevated rate of mortality necessitates a global challenge to explore …

Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Objective: The aim of the present review is to give an overview about the role, biosynthesis,
and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular …

Endophytic fungi became an attractive source for the discovery of new leads, because of the
complexity and the structural diversity of their secondary metabolites. The genus Fusarium …

Cancer is a major killer disease all over the world and more than six million new cases are
reported every year. Nature is an attractive source of new therapeutic compounds, as a …

Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important
products that exhibit various biological properties (eg, cytotoxic, insecticidal, antifungal …

Endophytic fungi are microorganisms that exist almost ubiquitously inside the various
tissues of living plants where they act as an important reservoir of diverse bioactive …

It is known that plant-based ethnomedicine represented the foundation of modern
pharmacology and that many pharmaceuticals are derived from compounds occurring in …

Endophytic fungi are a highly diverse group of fungi that intermittently colonize all plants
without causing symptoms of the disease. They sense and respond to physiological and …