[HTML][HTML] The coagulation system in host defense
S Antoniak - Research and Practice in Thrombosis and …, 2018 - Elsevier
The blood coagulation system and immune system of higher organisms are thought to have
a common ancestral origin. During infections, the blood coagulation system is activated and …
a common ancestral origin. During infections, the blood coagulation system is activated and …
The interplay between hemostasis and immune response in biomaterial development for osteogenesis
Abstract Treatment of large bone defects, particularly bone non-union, remains a clinical
challenge. The gold-standard bone substitute continues to be an autologous bone graft …
challenge. The gold-standard bone substitute continues to be an autologous bone graft …
Lipid presentation by the protein C receptor links coagulation with autoimmunity
N Müller-Calleja, A Hollerbach, J Royce, S Ritter… - Science, 2021 - science.org
INTRODUCTION Antiphospholipid antibodies (aPLs) transiently appear in infectious
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …
[HTML][HTML] Tissue factor at the crossroad of coagulation and cell signaling
H Zelaya, AS Rothmeier, W Ruf - Journal of thrombosis and haemostasis, 2018 - Elsevier
The tissue factor (TF) pathway plays a central role in hemostasis and thrombo‐inflammatory
diseases. Although structure‐function relationships of the TF initiation complex are …
diseases. Although structure‐function relationships of the TF initiation complex are …
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite
food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity …
food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity …
Beyond thrombosis: the impact of tissue factor signaling in cancer
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
Myeloid cell–synthesized coagulation factor X dampens antitumor immunity
C Graf, P Wilgenbus, S Pagel, J Pott, F Marini… - Science …, 2019 - science.org
Immune evasion in the tumor microenvironment (TME) is a crucial barrier for effective cancer
therapy, and plasticity of innate immune cells may contribute to failures of targeted …
therapy, and plasticity of innate immune cells may contribute to failures of targeted …
[HTML][HTML] Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy
AE Mast, W Ruf - Journal of Thrombosis and Haemostasis, 2022 - Elsevier
Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that
primarily dampens the initiation phase of coagulation before thrombin is generated. As such …
primarily dampens the initiation phase of coagulation before thrombin is generated. As such …
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke
Activated protein C (APC) cleaves protease-activated receptor 1 (PAR1) in vitro at R46 to
initiate beneficial cell signaling; however, thrombin and APC can cleave at R41. To elucidate …
initiate beneficial cell signaling; however, thrombin and APC can cleave at R41. To elucidate …
Novel tissue factor inhibition for thromboprophylaxis in COVID-19: primary results of the ASPEN-COVID-19 trial
BACKGROUND: Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF
(tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be …
(tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be …