Innovations in the Isolation and Treatment of Biofilms in Periprosthetic Joint Infection: A Comprehensive Review of Current and Emerging Therapies in Bone and Joint …

SA Ward, AA Habibi, I Ashkenazi, A Arshi… - Orthopedic …, 2024 - orthopedic.theclinics.com
Total joint arthroplasty (TJA) has been one of the most successful orthopedic surgeries
following its introduction in the 1960s, demonstrating both impressive survivorship and …

A Review of the Clinical Utilization of Oral Antibacterial Therapy in the Treatment of Bone Infections in Adults

N Haddad, J Ajaz, L Mansour, R Kasemodel, J Jarvis… - Antibiotics, 2023 - mdpi.com
Chronic osteomyelitis in adults is managed with prolonged courses of intravenous
antibiotics in conjunction with surgical debridement of necrotic bone. Over the past 40 years …

Comparative analysis of pathogen distribution in patients with fracture-related infection and periprosthetic joint infection: a retrospective study

T Ma, J Lyu, J Ma, X Huang, K Chen, S Wang… - BMC musculoskeletal …, 2023 - Springer
Background The purpose of this study is to investigate the microbial patterns of
periprosthetic joint infection (PJI) and fracture-related infection (FRI), and guide for the …

Microbiological trends and antibiotic susceptibility patterns in patients with periprosthetic joint infection of the hip or knee over 6 years

FS Fröschen, TM Randau, A Franz, E Molitor… - Antibiotics, 2022 - mdpi.com
We sought to analyze trends of the causative pathogens and their antibiotic susceptibility
patterns in patients with periprosthetic joint infections (PJI) of the hip and knee to get better …

Use of Hinged Implants for Multi-Stage Revision Knee Arthroplasty for Severe Periprosthetic Joint Infection: Remission Rate and Outcomes After a Minimum Follow-Up …

M Schnetz, L Ewald, T Jakobi, A Klug… - The Journal of …, 2025 - Elsevier
Background In severe periprosthetic joint infection after total knee arthroplasty (TKA),
multistage procedures are indicated for ongoing signs of infection after implant removal …

Inferior Outcomes for Patients Transferred Between Surgical Stages for Knee Periprosthetic Joint Infection

J Florance, J Chang, PJ Kelly, D Smith… - The Journal of …, 2024 - Elsevier
Background Periprosthetic joint infection (PJI) in total knee arthroplasty may result in 2-stage
revision surgery. There are limited data describing outcomes when the first stage is …

[HTML][HTML] Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance

B Huzum, AC Aprotosoaie, O Alexa, PD Sîrbu, B Puha… - Medicina, 2024 - mdpi.com
Orthopedic infections are challenging pathologies that impose a heavy burden on patients
and the healthcare system. Antimicrobial therapy is a critical component of the successful …

Phage Therapy Against Antibiotic‐Resistant and Multidrug‐Resistant Infections Involving Nonhealing Wounds and Prosthetic Joint Infections Associated With Biofilms …

K Haq, M Figgitt, D Lee - Canadian Journal of Infectious …, 2024 - Wiley Online Library
Chronic wounds and prosthetic joint infections are difficult to treat and are associated with a
high burden of disease and economic cost. The rise of antibiotic resistance and the …

Two-Stage Revision Arthroplasty for Resistant Gram-Positive Periprosthetic Joint Infections Using an Oral Linezolid-Based Antibiotic Regime

L Gründer, S Bockholt, G Gosheger, M Schulze… - Antibiotics, 2023 - mdpi.com
Background: Increasing antibiotic resistance has been reported as an issue in the systemic
treatment of periprosthetic joint infection (PJI). Linezolid offers the advantages of high oral …

Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or …

A Brüggemann, NP Hailer - Frontiers in Microbiology, 2025 - frontiersin.org
Background Periprosthetic joint infection (PJI) is a devastating complication following
arthroplasty of the hip or knee joint and can be challenging to treat, depending on the …