Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for
tissue homeostasis and cell signaling. These proteolytic activities are mediated …

Cell responses to the extracellular matrix depend on specific signaling events. These are
important from early development, through differentiation and tissue homeostasis, immune …

With the increased awareness about the importance of the composition, organization, and
stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to …

The remodeling of the extracellular matrix (ECM) by several protease families releases a
number of bioactive fragments, which regulate numerous biological processes such as …

It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of
enzymes play a key role in cancer development and progression along with many of the …

Syndecan-1 (SDC1, CD138) is a key cell surface adhesion molecule essential for
maintaining cell morphology and interaction with the surrounding microenvironment …

Under normal conditions, the cellular microenvironment is optimized for the proper
functioning of the tissues and organs. Cells recognize and communicate with the …

Extracellular matrix (ECM) components form a dynamic network of key importance for cell
function and properties. Key macromolecules in this interplay are syndecans (SDCs), a …

Early-use activity during circuit-specific critical periods refines brain circuitry by the coupled
processes of eliminating inappropriate synapses and strengthening maintained synapses …

Abstract Syndecan 2 (SDC2) belongs to a four‐member family of evolutionary conserved
small type I transmembrane proteoglycans consisting of a protein core to which …