Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

A‐to‐I RNA editing by ADARs is an abundant epitranscriptomic RNA‐modification in
metazoa. In mammals, Flna pre‐mRNA harbours a single conserved A‐to‐I RNA editing site …

Mechanical force–induced conformational changes in proteins underpin a variety of
physiological functions, typified in muscle contractile machinery. Mutations in the actin …

Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer's disease
(AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in …

Many proteins contribute to the contractile properties of muscles, most notably myosin thick
filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at …

Platelets are anucleate cells that are essential for hemostasis and wound healing. Upon
activation of the cell surface receptors by their corresponding extracellular ligands, platelets …

Filamin A (FLNA) is an actin cross-linking protein that mediates mechanotransduction. Force-
dependent conformational changes of FLNA molecule expose cryptic binding site of FLNA …

Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …

Triple-negative breast cancer is a rare but highly heterogeneous breast cancer subtype with
a limited choice of specific treatments. Chemotherapy remains the only efficient treatment …