Travelling the world of gene–gene interactions
K Van Steen - Briefings in bioinformatics, 2012 - academic.oup.com
Over the last few years, main effect genetic association analysis has proven to be a
successful tool to unravel genetic risk components to a variety of complex diseases. In the …
successful tool to unravel genetic risk components to a variety of complex diseases. In the …
An empirical comparison of several recent epistatic interaction detection methods
Motivation: Many new methods have recently been proposed for detecting epistatic
interactions in GWAS data. There is, however, no in-depth independent comparison of these …
interactions in GWAS data. There is, however, no in-depth independent comparison of these …
Genetic association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis
Z Lin, N Thorenoor, R Wu, SL DiAngelo, M Ye… - Frontiers in …, 2018 - frontiersin.org
Surfactant proteins (SP) are involved in surfactant function and innate immunity in the
human lung. Both lung function and innate immunity are altered in CF, and altered SP levels …
human lung. Both lung function and innate immunity are altered in CF, and altered SP levels …
Niche harmony search algorithm for detecting complex disease associated high-order SNP combinations
S Tuo, J Zhang, X Yuan, Z He, Y Liu, Z Liu - Scientific reports, 2017 - nature.com
Genome-wide association study is especially challenging in detecting high-order disease-
causing models due to model diversity, possible low or even no marginal effect of the model …
causing models due to model diversity, possible low or even no marginal effect of the model …
[HTML][HTML] Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease
AIM To study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-
10/STAT3 pathways in pediatric inflammatory bowel disease (IBD). METHODS A total of 159 …
10/STAT3 pathways in pediatric inflammatory bowel disease (IBD). METHODS A total of 159 …
High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions
There has been increased interest in discovering combinations of single-nucleotide
polymorphisms (SNPs) that are strongly associated with a phenotype even if each SNP has …
polymorphisms (SNPs) that are strongly associated with a phenotype even if each SNP has …
Single nucleotide polymorphisms interactions of the surfactant protein genes associated with respiratory distress syndrome susceptibility in preterm infants
S Amatya, M Ye, L Yang, CK Gandhi, R Wu… - Frontiers in …, 2021 - frontiersin.org
Background: Neonatal respiratory distress syndrome (RDS), due to surfactant deficiency in
preterm infants, is the most common cause of respiratory morbidity. The surfactant proteins …
preterm infants, is the most common cause of respiratory morbidity. The surfactant proteins …
Hidden risk genes with high-order intragenic epistasis in Alzheimer's disease
Meta-analysis of data from genome-wide association studies (GWAS) of Alzheimer's disease
(AD) has confirmed the high risk of APOE and identified twenty other risk genes/loci with …
(AD) has confirmed the high risk of APOE and identified twenty other risk genes/loci with …
SNP and haplotype interaction models reveal association of surfactant protein gene polymorphisms with hypersensitivity pneumonitis of Mexican population
Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by
inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role …
inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role …
Association of SNP–SNP interactions of surfactant protein genes with pediatric acute respiratory failure
The hallmarks of pediatric acute respiratory failure (ARF) are dysregulated inflammation and
surfactant dysfunction. The objective is to study association of surfactant protein (SP) genes' …
surfactant dysfunction. The objective is to study association of surfactant protein (SP) genes' …