Muscle–organ crosstalk: the emerging roles of myokines

MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

S Mohammed, N Thadathil, R Selvarani, EH Nicklas… - Aging cell, 2021 - Wiley Online Library
Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Fibro–adipogenic progenitors cross-talk in skeletal muscle: the social network

B Biferali, D Proietti, C Mozzetta, L Madaro - Frontiers in physiology, 2019 - frontiersin.org
Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling

Z Radak, Z Zhao, E Koltai, H Ohno… - Antioxidants & redox …, 2013 - liebertpub.com
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

[HTML][HTML] Muscle as an endocrine organ: focus on muscle-derived interleukin-6

BK Pedersen, MA Febbraio - Physiological reviews, 2008 - journals.physiology.org
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Muscle as a secretory organ

BK Pedersen - Comprehensive physiology, 2011 - Wiley Online Library
Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

Molecular inflammation: underpinnings of aging and age-related diseases

HY Chung, M Cesari, S Anton, E Marzetti… - Ageing research …, 2009 - Elsevier
Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review

C Kasapis, PD Thompson - Journal of the american College of Cardiology, 2005 - jacc.org
Physical activity is associated with a reduced incidence of coronary disease, but the
mechanisms mediating this effect are not defined. There has been considerable recent …

[HTML][HTML] Role of myokines in exercise and metabolism

BK Pedersen, TCA Åkerström… - Journal of applied …, 2007 - journals.physiology.org
During the past 20 yr, it has been well documented that exercise has a profound effect on
the immune system. With the discovery that exercise provokes an increase in a number of …