Methods for producing polypeptides by regulating polypeptide association

T Igawa, H Tsunoda - US Patent 10,011,858, 2018 - Google Patents
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Optimized FC variants

GA Lazar, W Dang, JR Desjarlais, SB Karki… - US Patent …, 2012 - Google Patents
2005-09-29 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …

Optimized Fc variants and methods for their generation

G Lazar, A Chirino, W Dang, J Desjarlais… - US Patent App. 10 …, 2004 - Google Patents
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Fc variants with altered binding to FcRn

AK Chamberlain, BI Dahiyat, JR Desjarlais… - US Patent …, 2013 - Google Patents
The present application relates to a variant Fc region com prising at least one modification
relative to a wild-type human Fc region, where the modification selected from the group …

Modified antibody constant region

T Igawa, H Shiraiwa - US Patent 9,688,762, 2017 - Google Patents
The present inventors Succeeded in improving the antibody constant region to have
increased stability under acid con ditions, reduced heterogeneity originated from disulfide …

Method of modifying isoelectric point of antibody via amino acid substitution in CDR

T Igawa, H Tsunoda, T Tachibana… - US Patent …, 2015 - Google Patents
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Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

T Igawa, S Ishii, A Maeda, T Nakai - US Patent App. 12/936,587, 2011 - Google Patents
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Fc variants

GA Lazar, W Dang, JR Desjarlais, SB Karki… - US Patent …, 2013 - Google Patents
2014-05-13 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …

Fc variants with altered binding to FcRn

AK Chamberlain, BI Dahiyat, JR Desjarlais… - US Patent …, 2014 - Google Patents
US8802820B2 - Fc variants with altered binding to FcRn - Google Patents US8802820B2 - Fc
variants with altered binding to FcRn - Google Patents Fc variants with altered binding to FcRn …

Immunoglobulin insertions, deletions and substitutions

GA Lazar, BI Dahiyat, W Dang, SB Karki… - US Patent …, 2012 - Google Patents
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl) anilino] pyrimidin-4-yl]
amino] phenyl] cyclopropanecarboxamide Chemical compound FC (F)(F) C1= CC= CC …