Lipidomics from sample preparation to data analysis: a primer

T Züllig, M Trötzmüller, HC Köfeler - Analytical and bioanalytical chemistry, 2020 - Springer
Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

Ultraviolet photodissociation mass spectrometry for analysis of biological molecules

JS Brodbelt, LJ Morrison, I Santos - Chemical reviews, 2019 - ACS Publications
The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

High resolution mass spectrometry in lipidomics

T Züllig, HC Köfeler - Mass spectrometry reviews, 2021 - Wiley Online Library
The boost of research output in lipidomics during the last decade is tightly linked to improved
instrumentation in mass spectrometry. Associated with this trend is the shift from low …

Dissociation of biomolecules by an intense low-energy electron beam in a high sensitivity time-of-flight mass spectrometer

T Baba, P Ryumin, E Duchoslav, K Chen… - Journal of the …, 2021 - ACS Publications
We report the progress on an electron-activated dissociation (EAD) device coupled to a
quadrupole TOF mass spectrometer (QqTOF MS) developed in our group. This device …

Advanced tandem mass spectrometry in metabolomics and lipidomics—methods and applications

S Heiles - Analytical and Bioanalytical Chemistry, 2021 - Springer
Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …

Large-scale lipid analysis with C=C location and sn-position isomer resolving power

W Cao, S Cheng, J Yang, J Feng, W Zhang, Z Li… - Nature …, 2020 - nature.com
Lipids play a pivotal role in biological processes and lipid analysis by mass spectrometry
(MS) has significantly advanced lipidomic studies. While the structure specificity of lipid …

Mass spectrometry imaging with isomeric resolution enabled by ozone‐induced dissociation

MRL Paine, BLJ Poad, GB Eijkel… - Angewandte Chemie …, 2018 - Wiley Online Library
Mass spectrometry imaging (MSI) enables the spatial distributions of molecules possessing
different mass‐to‐charge ratios to be mapped within complex environments revealing …

[HTML][HTML] Deep-lipidoty** by mass spectrometry: recent technical advances and applications

W Zhang, R Jian, J Zhao, Y Liu, Y **a - Journal of Lipid Research, 2022 - Elsevier
In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …

Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry

T **a, F Zhou, D Zhang, X **, H Shi, H Yin… - Nature …, 2023 - nature.com
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers

W Zhang, D Zhang, Q Chen, J Wu, Z Ouyang… - Nature …, 2019 - nature.com
Mass spectrometry-based lipidomics is the primary tool for the structural analysis of lipids but
the effective localization of carbon–carbon double bonds (C= C) in unsaturated lipids to …