[HTML][HTML] TRP channels in thermosensation
M Kashio, M Tominaga - Current Opinion in Neurobiology, 2022 - Elsevier
The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …
temperature information is converted to neural activity by afferent input to the central nervous …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
[HTML][HTML] Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive …
Background Long-term hormone therapy has been the standard of care for advanced
prostate cancer since the 1940s. STAMPEDE is a randomised controlled trial using a …
prostate cancer since the 1940s. STAMPEDE is a randomised controlled trial using a …
The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
Body temperature homeostasis is critical for survival and requires precise regulation by the
nervous system. The hypothalamus serves as the principal thermostat that detects and …
nervous system. The hypothalamus serves as the principal thermostat that detects and …
Peripheral thermosensation in mammals
Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
[HTML][HTML] Molecular mechanism of TRP channels
J Zheng - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …
[HTML][HTML] The sensory coding of warm perception
Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …
The thermoregulation system and how it works
AA Romanovsky - Handbook of clinical neurology, 2018 - Elsevier
Heat exchange processes between the body and the environment are introduced. The
definition of the thermoneutral zone as the ambient temperature range within which body …
definition of the thermoneutral zone as the ambient temperature range within which body …
Temperature sensation: from molecular thermosensors to neural circuits and coding principles
R **ao, XZS Xu - Annual review of physiology, 2021 - annualreviews.org
Temperature is a universal cue and regulates many essential processes ranging from
enzymatic reactions to species migration. Due to the profound impact of temperature on …
enzymatic reactions to species migration. Due to the profound impact of temperature on …