Biofilm signaling, composition and regulation in Burkholderia pseudomallei

PK Nyanasegran, S Nathan… - … of Microbiology and …, 2022 - pmc.ncbi.nlm.nih.gov
The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia
pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously …

Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

JS Izquierdo-Condoy, J Vasconez-Gonzales… - Frontiers in Cellular …, 2024 - frontiersin.org
Infectious diseases have consistently served as pivotal influences on numerous civilizations,
inducing morbidity, mortality, and consequently redirecting the course of history. Their …

Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

KB Barnes, P Brett, M Burtnick, A Vente… - Infection and …, 2024 - Am Soc Microbiol
Melioidosis is a disease that is difficult to treat due to the causative organism, Burkholderia
pseudomallei being inherently antibiotic resistant and it having the ability to invade, survive …

Role of the type 6 secretion system on apoptosis and macrophage polarization during Burkholderia pseudomallei infection

JL Stockton, N Khakhum, AG Torres - PLoS neglected tropical …, 2024 - journals.plos.org
Burkholderia pseudomallei (Bpm) is the causative agent of the disease melioidosis. As a
facultative intracellular pathogen, Bpm has a complex lifestyle that culminates in cell-to-cell …

Inhibition of macrophage infectivity potentiator in Burkholderia pseudomallei suppresses pro-inflammatory responses in murine macrophages

J Iwasaki, NM Bzdyl, DJM Lin-Sullivan… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Melioidosis, caused by the Gram-negative bacterium Burkholderia
pseudomallei, is a disease endemic in many tropical countries globally. Clinical …

Marmosets as models of infectious diseases

ICT Herron, TR Laws, M Nelson - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Animal models of infectious disease often serve a crucial purpose in obtaining licensure of
therapeutics and medical countermeasures, particularly in situations where human trials are …

Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis

KZ Xu, C You, YJ Wang, OI Dar, LJ Yin… - Medical Microbiology …, 2024 - Springer
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an
intracellular pathogen with a high mortality rate and significant antibiotic resistance. The …

Virulome and phylogenomic profiling of a novel Burkholderia pseudomallei strain from an Indian clinical isolate

MR Varshith, R Ghosh Dastidar, MS Shrilaxmi… - Molecular Genetics and …, 2024 - Springer
Highly pathogenic Burkholderia pseudomallei is the causative agent of melioidosis, a
neglected tropical disease endemic in Southeast Asian tropical region. This bacterium …

Type VI Secretion System Accessory Protein TagAB-5 Promotes Burkholderia pseudomallei Pathogenicity in Human Microglia

S Lohitthai, A Rungruengkitkun, N Jitprasutwit… - Biomedicines, 2023 - mdpi.com
Central nervous system (CNS) melioidosis caused by Burkholderia pseudomallei is being
increasingly reported. Because of the high mortality associated with CNS melioidosis …

TLR9 Negatively Regulates Intracellular Bacterial Killing by Pyroptosis in Burkholderia pseudomallei-Infected Mouse Macrophage Cell Line (Raw264.7)

M Pudla, S Sanongkiet, P Ekchariyawat… - Microbiology …, 2022 - Am Soc Microbiol
Melioidosis is a serious infectious disease caused by Burkholderia pseudomallei. This
bacterium is able to survive and multiply inside the immune cells such as macrophages. It is …