Investigation of Huisgen's Noble metal catalyst click reaction mechanism for the synthesis of 1, 4-disubstituted 1, 2, 3-triazoles

AA Khairbek, MI Al-Zaben, R Puchta, MAAH Badawi… - Molecular …, 2024 - Elsevier
The current study delves into the mechanistic intricacies of azide-alkyne cycloaddition
reactions (MAAC) catalyzed by transition metals (M= Cu, Ag, and Au) bound to N …

Assessing the catalytic potential of novel halogen substituted carbene NHC (F, Cl, Br, I) catalysts in [3+ 2] cycloaddition reactions: A computational investigation

AA Khairbek, MAAH Badawi, AY Alzahrani… - Dalton …, 2024 - pubs.rsc.org
This study investigated the catalytic behavior of NHC-X ligands (X= F, Cl, Br, I) in
cycloaddition reactions, focusing on both mononuclear and binuclear pathways. Using NCI …

Exploring the potential of metal-catalysis with N, N-type ligands in [3+ 2] cycloaddition reactions of azides and alkynes using theoretical tools

AA Khairbek, MI Al-Zaben, F Abbas… - Reaction Kinetics …, 2024 - Springer
In this study, we meticulously analyzed the catalysis of azide-alkyne [3+ 2] cycloaddition
reactions facilitated by metal-complexes with N, N-type ligands using MN12-L functional with …

Silver-and gold-catalyzed azide− alkyne cycloaddition by functionalized NHC-based polynuclear catalysts: Computational investigation and mechanistic insights

AA Khairbek, MAAH Badawi, AYA Alzahrani… - Molecular …, 2025 - Elsevier
This study evaluated the catalytic efficiency of Au (I), Ag (I), and Cu (I) complexes in the
azide‒alkyne cycloaddition (AAC) reaction through density functional theory (DFT) …

Computational study on novel RhCp X (X= CF 3, SiF 3, CCl 3, SO 3 H) as promising catalysts in the [3+ 2] azide–alkyne cycloaddition reaction: insights into …

AA Khairbek, MAAH Badawi, AY Alzahrani… - Dalton …, 2025 - pubs.rsc.org
This computational study investigated the catalytic efficiency of novel RhCpX complexes (X=
CF3, SiF3, CCl3, SO3H) in [3+ 2] azide–alkyne cycloaddition reactions via density functional …

Copper-bonded polyoxomolybdates-based framework as a heterogeneous catalyst for the cascade click reaction and bromination

S Fu, G Liu, S Liu, Z Gao, S Tao, Y Peng, N **n… - Molecular …, 2024 - Elsevier
The selective conversion of alkynes into bromotriazoles over a single-component catalyst is
highly desirable but presents significant challenges. In this study, we developed a robust …

Mechanistic and enantioselectivity analysis of amino acid-catalyzed asymmetric aldol reactions: a theoretical study

CX Yan, DF Li, LJ Yang, LX Fu, XQ Hua - Reaction Kinetics, Mechanisms …, 2025 - Springer
In this work, we theoretically studied the asymmetric aldol reactions between acetone and p-
NO2PhCHO catalyzed by (S)-proline,(S)-azetidine-2-carboxylic acid,(S)-pipecolic acid, L …