With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

R-loops involve in various biological processes under human normal physiological
conditions. Disruption of R-loops can lead to disease onset and affect the progression of …

Background Radiotherapy is an important strategy for the treatment of advanced gastric
cancer (GC), while the radioresistance limits its effectiveness. Nucleolar and spindle …

Background Disorder of cell cycle represents as a major driver of hepatocarcinogenesis and
constitutes an attractive therapeutic target. However, identifying key genes that respond to …

DHX9 is a member of the DEAH (Asp-Glu-Ala-His) helicase family and regulates DNA
replication and RNA processing. DHX9 dysfunction promotes tumorigenesis in several solid …

Purpose: After failing primary and secondary hormonal therapy, castration-resistant and
neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although …

Diabetic foot ulcer (DFU) is a destructive complication of diabetes. Negative pressure wound
therapy (NPWT) promotes DFU wound healing through an undetermined mechanism. In the …

The correct assembly of the spindle apparatus directly regulates the precise separation of
chromosomes in mouse oocytes, which is crucial for obtaining high‐quality oocytes capable …

R-loops are RNA-DNA hybrid structures that form when a newly synthesized RNA molecule
produced during transcription remains hybridized with the DNA template (Fig. 1). R-loops …

Abstract Background Hepatitis B virus (HBV) is a significant contributor to the development
of hepatocellular carcinoma (HCC). Chronic HBV infection (CHB) facilitates disease …