Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

Since the discovery of DNA, the normal develo** and functioning brain has been
assumed to be composed of cells with identical genomes, which remains the dominant view …

The diversity and complexity of the human brain are widely assumed to be encoded within a
constant genome. Somatic gene recombination, which changes germline DNA sequences to …

The transcriptional state of a cell reflects a variety of biological factors, from cell-type-specific
features to transient processes such as the cell cycle, all of which may be of interest …

In spite of the high metabolic cost of cellular production, the brain contains only a fraction of
the neurons generated during embryonic development. In the rodent cerebral cortex, a first …

Previous reports have shown that individual neurons of the brain can display somatic
genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism …

Intrauterine viral infections during pregnancy by pathogens such as Zika virus,
Cytomegalovirus, Rubella and Herpes Simplex virus can lead to prenatal as well as …

Somatic mutations are postzygotic mutations which may lead to mosaicism, the presence of
cells with genetic differences in an organism. Their role in cancer is well established, but …

Intercellular karyotypic variability has been a focus of genetic research for more than 50
years. It has been repeatedly shown that chromosome heterogeneity manifesting as …

Mosaicism, the presence of genomic differences between cells due to post-zygotic somatic
mutations, is widespread in the human body, including within the brain. A role for this in …