Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …

Immunotherapies that produce durable responses in some malignancies have failed in
pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor …

Immunohistochemistry (IHC) is a well-established and commonly used staining method for
clinical diagnosis and biomedical research. In most IHC images, the target protein is …

Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is
characterised by an iron-dependent accumulation of lipid peroxides. Therapy-resistant …

Abstract Purpose of Review Antibody–drug conjugates (ADCs) offer a promising path for
cancer therapy, leveraging the specificity of monoclonal antibodies and the cytotoxicity of …

In situ hybridization (ISH) is used for the localization of specific nucleic acid sequences in
cells or tissues by complementary binding of a nucleotide probe to a specific target nucleic …

Several reports previously investigated the Transient Receptor Potential Canonical
subfamily channel 3 (TRPC3) in the kidney. However, most of the conclusions are based on …

Transient receptor potential canonical sub-family channel 3 (TRPC3) is considered to play a
critical role in calcium homeostasis. However, there are no established findings in this …

Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of
disease and advancing development of improved vaccines and therapeutics. Pigs are …

Background Somatostatin receptors, and specifically somatostatin receptor type 2 (SSTR2),
have primarily been associated with neuroendocrine tumors and have revolutionized the …