Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives

D Tesauro, A Accardo, C Diaferia, V Milano, J Guillon… - Molecules, 2019 - mdpi.com
Peptides of natural and synthetic sources are compounds operating in a wide range of
biological interactions. They play a key role in biotechnological applications as both …

Fmoc-diphenylalanine hydrogels: Optimization of preparation methods and structural insights

C Diaferia, E Rosa, G Morelli, A Accardo - Pharmaceuticals, 2022 - mdpi.com
Hydrogels (HGs) are tri-dimensional materials with a non-Newtonian flow behaviour formed
by networks able to encapsulate high amounts of water or other biological fluids. They can …

Injectable alginate-peptide composite hydrogel as a scaffold for bone tissue regeneration

M Ghosh, M Halperin-Sternfeld, I Grinberg… - Nanomaterials, 2019 - mdpi.com
The high demand for tissue engineering scaffolds capable of inducing bone regeneration
using minimally invasive techniques prompts the need for the development of new …

Molecular simulations of PEGylated biomolecules, liposomes, and nanoparticles for drug delivery applications

H Lee - Pharmaceutics, 2020 - mdpi.com
Since the first polyethylene glycol (PEG) ylated protein was approved by the FDA in 1990,
PEGylation has been successfully applied to develop drug delivery systems through …

Differently N‐capped analogues of Fmoc‐FF

C Diaferia, E Rosa, E Gallo, G Morelli… - … –A European Journal, 2023 - Wiley Online Library
Short and ultra‐short peptides have been recently envisioned as excellent building blocks
for the formulation of hydrogels with appealing properties. Due to its simplicity and capability …

Amyloid-like aggregation in diseases and biomaterials: Osmosis of structural information

N Balasco, C Diaferia, G Morelli, L Vitagliano… - … in Bioengineering and …, 2021 - frontiersin.org
The discovery that the polypeptide chain has a remarkable and intrinsic propensity to form
amyloid-like aggregates endowed with an extraordinary stability is one of the most relevant …

Probing the Self-Aggregation of l-Tryptophan into Spherical Microstructures and Their Selective Interactions with Bilirubin

Aarya, A Sebastian, KP… - ACS Applied Bio …, 2025 - ACS Publications
The aggregation of proteins, peptides and amino acids has been a keen subject of interest
owing to their implications in metabolic disorders. In this work, we investigated the self …

Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids

LR de Mello, L Porosk, TC Lourenço… - ACS Applied Bio …, 2021 - ACS Publications
Cell-penetrating peptides (CPPs) are a topical subject potentially exploitable for creating
nanotherapeutics for the delivery of bioactive loads. These compounds are often classified …

Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers

A Mosseri, M Sancho-Albero, FA Mercurio… - Bioconjugate …, 2023 - ACS Publications
Peptide nucleic acids and their conjugates to peptides can self-assemble and generate
complex architectures. In this work, we explored the self-assembly of PNA dimers …

The introduction of a cysteine residue modulates the mechanical properties of aromatic‐based solid aggregates and self‐supporting hydrogels

C Diaferia, E Rosa, N Balasco… - … A European Journal, 2021 - Wiley Online Library
Peptide‐based hydrogels, originated by multiscale self‐assembling phenomenon, have
been proposed as multivalent tools in different technological areas. Structural studies and …