Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Cytokines are proteins secreted in the central nervous system by neurons, microglia,
astrocytes and infiltrating peripheral immune cells under physiological and pathological …

During infection, animals exhibit adaptive changes in physiology and behaviour aimed at
increasing survival. Although many causes of infection exist, they trigger similar stereotyped …

Within minutes of a traumatic impact, a robust inflammatory response is elicited in the injured
brain. The complexity of this post-traumatic squeal involves a cellular component …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …

The emerging literature implicates a role for glia/cytokines in persistent pain. However, the
mechanisms by which these non-neural elements contribute to CNS activity-dependent …

The Toll/interleukin-1 (IL-1) receptor (TIR) family comprises two groups of transmembrane
proteins, which share functional and structural properties. The members of the IL-1 receptor …

Publisher Summary This chapter highlights the controversies concerning the role of brain
inflammation elicited after brain trauma. In clinical practice, classification of primary brain …

EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream
substrates upon binding of ephrin cell surface–associated ligands. In a large cohort of …