Ischaemic heart disease (IHD) is the leading cause of death and disability worldwide. The
pathophysiological effects of IHD on the heart most often result from the detrimental effects of …

Background and purpose: The mitochondrial permeability transition pore (mPTP), an energy‐
dissipating channel activated by calcium, contributes to reperfusion damage by depolarizing …

Mitochondrial dysfunction is a hallmark of multiple cardiovascular disorders, including
ischemic heart disease. Although mitochondria are well recognized for their role in energy …

Abstract Copper-based drugs, Casiopeinas (Cas), exhibit antiproliferative and antineoplastic
activities in vitro and in vivo, respectively. Unfortunately, the clinical use of these novel …

Ca2+ plays a pivotal role in mitochondrial energy production, contraction, and apoptosis.
Mitochondrial Ca2+-targeted fluorescent probes have demonstrated that mitochondria Ca2+ …

Background Detoxification of aldehydes by aldehyde dehydrogenases (ALDHs) is crucial to
maintain cell function. In cardiovascular diseases, reactive oxygen species generated during …

Common arrhythmias, particularly atrial fibrillation (AF) and ventricular
tachycardia/fibrillation (VT/VF) are a major public health concern. Classic antiarrhythmic …

The mitochondrial dysfunction in ischaemia‐reperfusion is shortly reviewed. During
ischaemia the ATP level and pH drops, phospholipids are degraded, membrane …

The critical role of mitochondria in cardiomyocyte survival and death has become an exciting
field of research in cardiac biology. Indeed, it is accepted that mitochondrial dysfunction …

Renal transplant recipients have a high incidence of hypertension, a known risk factor for
atrial fibrillation (AF), as well as factors that could increase their risk of AF. However, the …