Pre-eclampsia
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …
Evaluating the promise of inclusion of African ancestry populations in genomics
AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …
known, and the resultant scientific and ethical limitations are becoming increasingly …
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal
health. In genome-wide association meta-analysis of European and Central Asian mothers …
health. In genome-wide association meta-analysis of European and Central Asian mothers …
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …
act prematurely and is associated with multiple forms of psychopathology, including …
Alcohol and hypertension—new insights and lingering controversies
Abstract Purpose of Review To examine outstanding issues in the relationship of alcohol to
hypertension. These include whether the increase in BP with alcohol is causally related, the …
hypertension. These include whether the increase in BP with alcohol is causally related, the …
[HTML][HTML] The HERITAGE Family Study: a review of the effects of exercise training on cardiometabolic health, with insights into molecular transducers
The aim of the HERITAGE Family Study was to investigate individual differences in response
to a standardized endurance exercise program, the role of familial aggregation, and the …
to a standardized endurance exercise program, the role of familial aggregation, and the …
Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first
identify variants that are associated with breast cancer at P< 0.05 from African ancestry …
identify variants that are associated with breast cancer at P< 0.05 from African ancestry …
Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits
Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …
Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines
Risk factors for hypertension consist of lifestyle and genetic factors. Family history and twin
studies have yielded heritability estimates of BP in the range of 34–67%. The most recent …
studies have yielded heritability estimates of BP in the range of 34–67%. The most recent …
Gene-lifestyle interactions in the genomics of human complex traits
V Laville, T Majarian, YJ Sung, K Schwander… - European Journal of …, 2022 - nature.com
The role and biological significance of gene-environment interactions in human traits and
diseases remain poorly understood. To address these questions, the CHARGE Gene …
diseases remain poorly understood. To address these questions, the CHARGE Gene …