Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

Hypertension affects more than one billion people worldwide. Here we identify 113 novel
loci, reporting a total of 2,103 independent genetic signals (P< 5× 10− 8) from the largest …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal
health. In genome-wide association meta-analysis of European and Central Asian mothers …

The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Abstract Purpose of Review To examine outstanding issues in the relationship of alcohol to
hypertension. These include whether the increase in BP with alcohol is causally related, the …

Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …

Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …

The aim of the HERITAGE Family Study was to investigate individual differences in response
to a standardized endurance exercise program, the role of familial aggregation, and the …