Physics of cell adhesion: some lessons from cell-mimetic systems

E Sackmann, AS Smith - Soft matter, 2014 - pubs.rsc.org
Cell adhesion is a paradigm of the ubiquitous interplay of cell signalling, modulation of
material properties and biological functions of cells. It is controlled by competition of short …

Adhesion of membranes via receptor–ligand complexes: Domain formation, binding cooperativity, and active processes

TR Weikl, M Asfaw, H Krobath, B Różycki, R Lipowsky - Soft Matter, 2009 - pubs.rsc.org
Cell membranes interact via anchored receptor and ligand molecules. Central questions on
cell adhesion concern the binding affinity of these membrane-anchored molecules, the …

Cooperativity between trans and cis interactions in cadherin-mediated junction formation

Y Wu, X **, O Harrison, L Shapiro… - Proceedings of the …, 2010 - National Acad Sciences
Intercellullar junctions formed by cadherins, including desmosomes and adherens junctions,
comprise two dimensional arrays of “trans” dimers formed between monomers emanating …

Kinetics of membrane adhesion mediated by ligand–receptor interaction studied with a biomimetic system

A Boulbitch, Z Guttenberg, E Sackmann - Biophysical Journal, 2001 - cell.com
We report the first measurement of the kinetics of adhesion of a single giant vesicle
controlled by the competition between membrane–substrate interaction mediated by ligand …

The role of binder mobility in spontaneous adhesive contact and implications for cell adhesion

LB Freund, Y Lin - Journal of the Mechanics and Physics of Solids, 2004 - Elsevier
The standard view of mechanical adhesive contact is as a competition between a reduction
in free energy when surfaces with bonding potential come into contact and an increase in …

Binding constants of membrane-anchored receptors and ligands: A general theory corroborated by Monte Carlo simulations

GK Xu, J Hu, R Lipowsky, TR Weikl - The Journal of chemical physics, 2015 - pubs.aip.org
Adhesion processes of biological membranes that enclose cells and cellular organelles are
essential for immune responses, tissue formation, and signaling. These processes depend …

Growth and shape stability of a biological membrane adhesion complex in the diffusion-mediated regime

VB Shenoy, LB Freund - Proceedings of the National …, 2005 - National Acad Sciences
We examine the process of expansion of a focal adhesion complex by which a biological
membrane containing mobile binders adheres to a substrate with complementary binders …

Theoretical concepts and models of cellular mechanosensing

R De, A Zemel, SA Safran - Methods in cell biology, 2010 - Elsevier
Recent discoveries have established that mechanical properties of the cellular environment
such as its rigidity, geometry, and external stresses play an important role in determining the …

Supported membranes on chemically structured and rough surfaces

PS Swain, D Andelman - Physical Review E, 2001 - APS
We present a general linear response description of membrane adhesion at rough or
chemically structured surfaces. Our method accounts for nonlocal Van der Waals effects and …

Segregation of receptor–ligand complexes in cell adhesion zones: phase diagrams and the role of thermal membrane roughness

B Różycki, R Lipowsky, TR Weikl - New journal of Physics, 2010 - iopscience.iop.org
The adhesion zone of immune cells, the'immunological synapse', exhibits characteristic
domains of receptor–ligand complexes. The domain formation is probably caused by a …