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Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer
Intravesical BCG instillation is the gold-standard adjuvant immunotherapy for patients with
high-risk non-muscle-invasive bladder cancer. However, the precise mechanism of action by …
high-risk non-muscle-invasive bladder cancer. However, the precise mechanism of action by …
Heat shock proteins and HSF1 in cancer
AM Cyran, A Zhitkovich - Frontiers in oncology, 2022 - frontiersin.org
Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …
activities of protein chaperones and proteolytic machinery. Upon encountering protein …
Immunotherapy against several tumors, such as lung cancer, including NSCLC
T Weinschenk, S Walter, J Fritsche, S Colette… - US Patent …, 2018 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Clinical, prognostic and therapeutic significance of heat shock proteins in cancer
Background: Heat Shock Proteins (HSPs) constitute a group of proteins that play a crucial
role in the process of protein folding. HSPs are also known to modulate a number of key …
role in the process of protein folding. HSPs are also known to modulate a number of key …
Immunotherapy against several tumors, such as lung cancer, including nsclc
T Weinschenk, S Walter, J Fritsche… - US Patent App. 14 …, 2016 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets?
Heat shock proteins (HSP) are a family of proteins induced in cells exposed to different
insults. This induction of HSPs allows cells to survive stress conditions. Mammalian HSPs …
insults. This induction of HSPs allows cells to survive stress conditions. Mammalian HSPs …
Novel immunotherapy against several tumors, such as lung cancer, including nsclc
T Weinschenk, S Walter, J Fritsche, S Colette, H Singh - 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones
Hsp70 (heat shock protein 70 kDa) chaperones are key to cellular protein homeostasis.
However, they also have the ability to inhibit tumor apoptosis and contribute to aberrant …
However, they also have the ability to inhibit tumor apoptosis and contribute to aberrant …
The involvement of JAK-STAT3 in cell motility, invasion, and metastasis
JAK-STAT3 signaling, while regulating many aspects of cancer development and
progression, promotes invasion and metastasis through activation of key metastasis …
progression, promotes invasion and metastasis through activation of key metastasis …
Similarities and differences of Hsp70, hsc70, Grp78 and mortalin as cancer biomarkers and drug targets
Abstract Background: Upregulation of Heath Shock Protein 70 (HSP70) chaperones
supports cancer cell survival. Their high homology causes a challenge to differentiate them …
supports cancer cell survival. Their high homology causes a challenge to differentiate them …