Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …

Background Primary Sjögren syndrome (pSS) is a chronic inflammatory autoimmune
disease that is characterized by lymphocytic infiltration of the exocrine glands and …

Our understanding of the biology of aging has advanced significantly in recent years. This
has resulted in the recent formulation of the “hallmarks of aging” that include genomic …

Epithelial-mesenchymal transition (EMT) plays a critical role in embryonic development,
wound healing, tissue regeneration, cancer progression and organ fibrosis. The proximal …

Simple Summary Fibrosis can affect almost every organ and represents an increasing cause
of morbidity and mortality worldwide. Despite significant progress in our understanding of …

The Homeodomain-interacting protein kinase (Hipk) family of proteins plays diverse, and at
times conflicting, biological roles in normal development and disease. In this review we will …

Background HMGB1 and ER stress have been considered to participate in the progression
of pulmonary artery hypertension (PAH). However, the molecular mechanism underlying …

Renal fibrosis is the final common pathway of all varieties of progressive chronic kidney
disease. However, there are no effective therapies to prevent or slow the progression of …

Idiopathic pulmonary fibrosis (IPF) is the most common and most lethal type of idiopathic
interstitial pneumonia. It is a chronic, aging-associated lung disease characterized by fibrotic …