Same substrate, many reactions: oxygen activation in flavoenzymes

E Romero, JR Gómez Castellanos, G Gadda… - Chemical …, 2018 - ACS Publications
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …

Flavoenzymes

V Joosten, WJH van Berkel - Current opinion in chemical biology, 2007 - Elsevier
Flavoenzymes are colourful oxidoreductases that catalyze a large variety of different types of
reactions. Flavoenzymes have been extensively studied for their structural and mechanistic …

Detoxification of azo dyes by bacterial oxidoreductase enzymes

S Mahmood, A Khalid, M Arshad… - Critical reviews in …, 2016 - Taylor & Francis
Azo dyes and their intermediate degradation products are common contaminants of soil and
groundwater in develo** countries where textile and leather dye products are produced …

Discovery of a thermostable Baeyer–Villiger monooxygenase by genome mining

MW Fraaije, J Wu, DPHM Heuts… - Applied Microbiology …, 2005 - Springer
Baeyer–Villiger monooxygenases represent useful biocatalytic tools, as they can catalyze
reactions which are difficult to achieve using chemical means. However, only a limited …

Recent trends and novel concepts in cofactor-dependent biotransformations

S Kara, JH Schrittwieser, F Hollmann… - Applied Microbiology …, 2014 - Springer
Cofactor-dependent enzymes catalyze a broad range of synthetically useful transformations.
However, the cofactor requirement also poses economic and practical challenges for the …

Biochemical and molecular characterization of an azoreductase from Staphylococcus aureus, a tetrameric NADPH-dependent flavoprotein

H Chen, SL Hopper, CE Cerniglia - Microbiology, 2005 - microbiologyresearch.org
Azo dyes are a predominant class of colourants used in tattooing, cosmetics, foods and
consumer products. A gene encoding NADPH-flavin azoreductase (Azo1) from the skin …

Dynamics of human mitochondrial complex I assembly: implications for neurodegenerative diseases

G Giachin, R Bouverot, S Acajjaoui… - Frontiers in molecular …, 2016 - frontiersin.org
Neurons are extremely energy demanding cells and highly dependent on the mitochondrial
oxidative phosphorylation (OXPHOS) system. Mitochondria generate the energetic potential …

What's in a covalent bond? On the role and formation of covalently bound flavin cofactors

DPHM Heuts, NS Scrutton, WS McIntire… - The FEBS …, 2009 - Wiley Online Library
Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors
may be bound to the enzyme in a noncovalent or covalent manner. Although most …

Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities

T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Photo-induced degradation of some flavins in aqueous solution

W Holzer, J Shirdel, P Zirak, A Penzkofer, P Hegemann… - Chemical Physics, 2005 - Elsevier
The blue-light induced photo-degradation of FMN, FAD, riboflavin, lumiflavin, and
lumichrome in aqueous solution at pH 8 is studied by measurement of absorption coefficient …