Multivalent interactions can be applied universally for a targeted strengthening of an
interaction between different interfaces or molecules. The binding partners form cooperative …

In biology, nucleic acids are carriers of molecular information: DNA's base sequence stores
and imparts genetic instructions, while RNA's sequence plays the role of a messenger and a …

Base-pair-driven toehold-mediated strand displacement (BP-TMSD) is a fundamental
concept employed for constructing DNA machines and networks with a gamut of …

Although many cellular processes depend upon enzymatic reactions, protein–protein
interactions (PPIs) mediate a large number of important regulatory pathways and thus play a …

To realize the full potential of the CRISPR/Cas system and expand its applicability up to the
detection of molecular interactions, we herein describe a novel method to identify …

We report a DNA machine that can reversibly regulate target binding affinity on the basis of
distance-dependent bivalent binding. It is a tweezer-like DNA machine that can tune the …

Based on small molecule-linked DNA and the nicking endonuclease-assisted amplification
(NEA) strategy, a novel electrochemical method for protein detection is proposed in this …

Optical cross‐reactive sensor arrays (the so‐called chemical “noses/tongues”) have recently
been demonstrated as a powerful tool for high‐throughput protein detecting and analysis …

The unfathomable role that fluorescence detection plays in the life sciences has prompted
the development of countless fluorescent labels, sensors, and analytical techniques that can …

We demonstrate a novel concept for the construction of a label‐free, quadruplex‐based
functional molecular beacon (LFG4‐MB) by using G‐quadruplex motif as a substitute for …