Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Risks of infectious disease in xenotransplantation

JA Fishman - New England Journal of Medicine, 2022 - Mass Medical Soc
Risks of Infectious Disease in Xenotransplantation | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Penaeid shrimp genome provides insights into benthic adaptation and frequent molting

X Zhang, J Yuan, Y Sun, S Li, YI Gao, Y Yu… - Nature …, 2019 - nature.com
Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of
major importance in ecology and fisheries. Here we report the genome sequence of the …

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

D Niu, HJ Wei, L Lin, H George, T Wang, IH Lee… - Science, 2017 - science.org
Xenotransplantation is a promising strategy to alleviate the shortage of organs for human
transplantation. In addition to the concerns about pig-to-human immunological compatibility …

The Ensembl gene annotation system

BL Aken, S Ayling, D Barrell, L Clarke, V Curwen… - Database, 2016 - academic.oup.com
The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Building a livestock genetic and genomic information knowledgebase through integrative developments of Animal QTLdb and CorrDB

ZL Hu, CA Park, JM Reecy - Nucleic acids research, 2019 - academic.oup.com
Successful development of biological databases requires accommodation of the burgeoning
amounts of data from high-throughput genomics pipelines. As the volume of curated data in …

Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits

L Chen, Q Qiu, YU Jiang, K Wang, Z Lin, Z Li, F Bibi… - Science, 2019 - science.org
INTRODUCTION The ruminants are one of the most successful mammalian lineages,
exhibiting extensive morphological and ecological diversity and containing several key …

Evolution of the ancestral mammalian karyotype and syntenic regions

J Damas, M Corbo, J Kim… - Proceedings of the …, 2022 - National Acad Sciences
Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …

Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

A reference gene catalogue of the pig gut microbiome

L **ao, J Estellé, P Kiilerich, Y Ramayo-Caldas… - Nature …, 2016 - nature.com
The pig is a major species for livestock production and is also extensively used as the
preferred model species for analyses of a wide range of human physiological functions and …