We disclose a benzylic C− H oxidative coupling reaction with alcohols that proceeds through
a synergistic deprotonation, halogenation and substitution sequence. The combination of …

The type II NADH-dehydrogenase enzyme in Mycobacterium tuberculosis plays a critical
role in the efficient functioning of the oxidative phosphorylation pathway. It acts as the entry …

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a prevalent
infectious disease affecting populations worldwide. A classic trait of TB pathology is the …

Bacterial infections, especially induced by multidrug-resistant pathogens, have become a
significant global health concern. In the infected tissues, biofilms not only serve as a source …

Bedaquiline, a highly lipophilic molecule, is used in the treatment regimen of multi-drug
resistant tuberculosis. A rare complication of pulmonary tuberculosis is tuberculous …

Selenyl quinolines are an important class of compounds that have found significant
applications in pharmaceuticals and synthetic chemistry. Herein, we describe an …

Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of
death globally. The treatment of patients becomes much more difficult for the increasingly …

Unveiling novel pathways for drug discovery forms the foundation of a new era in the combat
against tuberculosis. The discovery of a novel drug, bedaquiline, targeting mycobacterial …

A novel synthesis strategy to access 2-alkoxyquinoline derivatives via a palladium-driven
cascade reaction is disclosed. Unlike classic methods based on the alkylation of 2 …

In contrast to traditional multi-step routes, C–H functionalization offers a resource and time
efficient route to desired products. Current methods for oxidative C–H functionalization are …