Clinical diagonal translation of nanoparticles: Case studies in dendrimer nanomedicine
Among the numerous nanomedicine formulations, dendrimers have emerged as original,
efficient, carefully assembled, hyperbranched, polymeric nanoparticles based on synthetic …
efficient, carefully assembled, hyperbranched, polymeric nanoparticles based on synthetic …
Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications
Macroautophagy (hereafter autophagy), a tightly regulated physiological process that
obliterates dysfunctional and damaged organelles and proteins, has a crucial role when …
obliterates dysfunctional and damaged organelles and proteins, has a crucial role when …
Inhalable resveratrol-cyclodextrin complex loaded biodegradable nanoparticles for enhanced efficacy against non-small cell lung cancer
Resveratrol (RES), a natural polyphenol in fruits, has shown promising anti-cancer
properties. Due to its relative low toxicity which limits the adverse effects observed for …
properties. Due to its relative low toxicity which limits the adverse effects observed for …
Development and characterization of inhaled nintedanib-loaded PLGA nanoparticles using scalable high-pressure homogenization technique
Presently, non-invasive targeted drug delivery to the lungs represents a routinely
investigated approach to treat challenging disorders such as pulmonary fibrosis. Nintedanib …
investigated approach to treat challenging disorders such as pulmonary fibrosis. Nintedanib …
Poly vinyl pyrrolidone (PVP) based inhaled delivery carriers for olaparib for non-small cell lung cancer (NSCLC) treatment
Non-small cell lung cancer (NSCLC) is ranked first worldwide amongst deadly cancers with
poor patient survival rate. While chemotherapy, radiation and surgery are available …
poor patient survival rate. While chemotherapy, radiation and surgery are available …
Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment
The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated
polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial …
polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial …
Small-molecule Gankyrin inhibition as a therapeutic strategy for breast and lung cancer
Gankyrin is an oncoprotein responsible for the development of numerous cancer types. It
regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; …
regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; …
Development and characterization of inhalable transferrin functionalized amodiaquine nanoparticles–Efficacy in Non-Small Cell Lung Cancer (NSCLC) treatment
New drug discovery and development processes encounter significant challenges including
requirement of huge investments and lengthy time frames especially in cancer research …
requirement of huge investments and lengthy time frames especially in cancer research …
Bypassing P-glycoprotein mediated efflux of afatinib by cyclodextrin complexation–Evaluation of intestinal absorption and anti-cancer activity
A cyclodextrin complex of afatinib, a FDA-approved pan–ErbB inhibitor and known P-gp
substrate, was developed to enhance its bio-activity while also reducing p-glycoprotein (P …
substrate, was developed to enhance its bio-activity while also reducing p-glycoprotein (P …
Bioinspired particle engineering for non-invasive inhaled drug delivery to the lungs
Pulmonary drug delivery is governed by several biophysical parameters of delivery carriers,
such as particle size, shape, density, charge, and surface modifications. Although much …
such as particle size, shape, density, charge, and surface modifications. Although much …