The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …

Staphylococcus aureus is a major cause of nosocomial and community-acquired infections
and represents a significant burden on the healthcare system. S. aureus attachment to …

Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

Persisters are dormant phenotypic variants of bacterial cells that are tolerant to killing by
antibiotics 1. Persisters are associated with chronic infections and antibiotic treatment failure …

Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …

Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

During stress, bacteria undergo extensive physiological transformations, many of which are
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …

Biofilm-related infections account for at least 65% of all human infections, but there are no
available antimicrobials that specifically target biofilms. Their elimination by available …

Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …