Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

The identification of gene fusions from RNA sequencing data is a routine task in cancer
research and precision oncology. However, despite the availability of many computational …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …

Accurate identification of tumor-derived somatic variants in plasma circulating cell-free DNA
(cfDNA) requires understanding of the various biological compartments contributing to the …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Single-cell RNA sequencing studies have suggested that total mRNA content correlates with
tumor phenotypes. Technical and analytical challenges, however, have so far impeded at …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …