Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …

A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed
and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these …

Background: 4-Hydroxyquinolin-2-ones and quinoline-2, 4-diones, a subset of the quinolone
scaffold, have attracted attention due to their biological properties. These structures are …

The development of multitargeted therapeutics has evolved as a promising strategy to
identify efficient therapeutics for neurological disorders. We report herein new quinolinone …

A series of novel quinolinone–chalcone hybrids and analogues were designed, synthesized
and their biological activity against the mammalian stages of Trypanosoma brucei and …

Abstract Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol
biosynthesis. They serve as clinical targets for antifungal azoles and are considered as …

We describe here a novel procedure for the synthesis of highly substituted 2‐quinolinones.
By this newly developed approach, 2‐quinolinone derivatives were prepared in moderate to …

Diselenide and sulfonamide derivatives have recently attracted considerable interest as
leishmanicidal agents in drug discovery. In this study, a novel series of sixteen hybrid …

Amphotericin B (AmB) is effective against visceral leishmaniasis (VL), but the renal toxicity of
the conventional form, mixed micelles with deoxycholate (M-AmB), is often dose-limiting …

A method of furo-annulation of 4-hydroxy-2-oxoquinoline-3-carboxylates with 3-arylazirines
under Cu (II) catalysis was developed to synthesize a variety of 2, 3-dihydrofuro [3, 2-c] …