Highlights•Few classes of antifungal drugs currently exist to treat fungal infections.•Infections
caused by Candida biofilms can be resistant to known antifungal drugs.•Growth in the …

The extracellular matrix is a critical component of microbial biofilms, such as dental plaque,
maintaining the spatial arrangement of cells and coordinating cellular functions throughout …

Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix
is composed of a complex array of extracellular polymeric substances (EPS) that contribute …

Worldwide, the number of infections caused by biofilm-forming fungal pathogens is very
high. In human medicine, there is an increasing proportion of immunocompromised patients …

The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

Candida species are fungal pathogens known for their ability to cause superficial and
systemic infections in the human host. These pathogens are able to persist inside the host …

Candida albicans is a common fungus of the human microbiota. While generally a harmless
commensal in healthy individuals, several factors can lead to its overgrowth and cause a …

Candida albicans is among the most prevalent fungal species of the human microbiota and
asymptomatically colonizes healthy individuals. However, it is also an opportunistic …

A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed
communities of cells adhered to a surface. These biofilms are intrinsically resistant to …

In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …