Comparative efficacy and tolerability of pharmacological treatments for the treatment of acute bipolar depression: a systematic review and network meta-analysis
Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …
Glutamatergic dysfunction and glutamatergic compounds for major psychiatric disorders: evidence from clinical neuroimaging studies
Excessive glutamate release has been linked to stress and many neurodegenerative
diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or …
diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or …
Glutamatergic neurotransmission: pathway to develo** novel rapid-acting antidepressant treatments
The underlying neurobiological basis of major depressive disorder remains elusive due to
the severity, complexity, and heterogeneity of the disorder. While the traditional …
the severity, complexity, and heterogeneity of the disorder. While the traditional …
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA …
Highlights•Monoamine deficiency hypothesis cannot explain the neurobiology of mood
disorders.•Amino acid neurotransmitters are central to the pathophysiology of mood …
disorders.•Amino acid neurotransmitters are central to the pathophysiology of mood …
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
Comorbidity exists between metabolic disorders and depressive syndrome with unclear
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …
The neuroprotective and neuroplastic potential of glutamatergic therapeutic drugs in bipolar disorder
The monoamine hypothesis has dominated research on the pathophysiology of mood
disorders as well as the development of therapeutic drugs by over half a century. Nowadays …
disorders as well as the development of therapeutic drugs by over half a century. Nowadays …
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool
Riluzole is a potent neuroprotective agent which primarily inhibits excitatory
neurotransmission interfering with presynaptic release, uptake and postsynaptic actions of …
neurotransmission interfering with presynaptic release, uptake and postsynaptic actions of …
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway
Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade
apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive …
apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive …
Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder
Background Glutamergic system dysfunction has been implicated in the pathophysiology of
bipolar depression. This is an update of the 2015 Cochrane Review for the use of glutamate …
bipolar depression. This is an update of the 2015 Cochrane Review for the use of glutamate …
Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression
Growing evidence suggests that the glutamatergic modulator ketamine has rapid
antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent …
antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent …