Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

A number of different intracellular signaling pathways have been shown to be activated by
receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 …

Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Apoptosis plays an important role during neuronal development, and defects in apoptosis
may underlie various neurodegenerative disorders. To characterize molecular mechanisms …

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio …

Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich
Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be
grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in …