Liquid biopsy: from discovery to clinical application

C Alix-Panabières, K Pantel - Cancer discovery, 2021 - aacrjournals.org
Over the past 10 years, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA)
have received enormous attention as new biomarkers and subjects of translational research …

Cancer immunotherapy update: FDA-approved checkpoint inhibitors and companion diagnostics

JD Twomey, B Zhang - The AAPS journal, 2021 - Springer
Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many
cancer indications. This review provides an update on ICIs approved by the Food and Drug …

Liquid biopsy enters the clinic—implementation issues and future challenges

M Ignatiadis, GW Sledge, SS Jeffrey - Nature reviews Clinical oncology, 2021 - nature.com
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour
cells in peripheral blood have provided crucial insights into cancer biology and the …

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

L Keller, Y Belloum, H Wikman, K Pantel - British journal of cancer, 2021 - nature.com
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance

T Pereira-Veiga, S Schneegans, K Pantel, H Wikman - Cell Reports, 2022 - cell.com
Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

[HTML][HTML] Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer

P Kumar, S Gupta, BC Das - Translational oncology, 2024 - Elsevier
Head and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in
India and southeast Asia. It is a preventable and curable disease if detected early. Tobacco …

Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis

Q Pei, Y Luo, Y Chen, J Li, D **e, T Ye - Clinical Chemistry and …, 2022 - degruyter.com
Artificial intelligence (AI) is a branch of computer science that includes research in robotics,
language recognition, image recognition, natural language processing, and expert systems …

Liquid biopsies: Potential and challenges

I Heidrich, L Ačkar… - … Journal of Cancer, 2021 - Wiley Online Library
The analysis of tumor cells or tumor cell products obtained from blood or other body fluids
(“liquid biopsy”[LB]) provides a broad range of opportunities in the field of oncology. Clinical …

Advancing to the era of cancer immunotherapy

Y Wang, M Wang, HX Wu, RH Xu - Cancer communications, 2021 - Wiley Online Library
Cancer greatly affects the quality of life of humans worldwide and the number of patients
suffering from it is continuously increasing. Over the last century, numerous treatments have …