Computational tools to unmask transposable elements

P Goerner-Potvin, G Bourque - Nature Reviews Genetics, 2018 - nature.com
A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …

The developmental control of transposable elements and the evolution of higher species

M Friedli, D Trono - Annual review of cell and developmental …, 2015 - annualreviews.org
Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

CC Smith, KE Beckermann, DS Bortone… - The Journal of …, 2019 - Am Soc Clin Investig
Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have
integrated into the genome throughout evolution. We developed a computational workflow …

Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs

A Kapusta, Z Kronenberg, VJ Lynch, X Zhuo… - PLoS …, 2013 - journals.plos.org
Advances in vertebrate genomics have uncovered thousands of loci encoding long
noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory …

Regulation of human MAPT gene expression

ML Caillet-Boudin, L Buée, N Sergeant… - Molecular …, 2015 - Springer
The number of known pathologies involving deregulated Tau expression/metabolism is
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …

Intronic Alus Influence Alternative Splicing

G Lev-Maor, O Ram, E Kim, N Sela, A Goren… - PLoS …, 2008 - journals.plos.org
Examination of the human transcriptome reveals higher levels of RNA editing than in any
other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) …

[HTML][HTML] Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?

JM Antony, AM DesLauriers, RK Bhat… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Human endogenous retroviruses (HERVs) constitute 5–8% of human genomic DNA and are
replication incompetent despite expression of individual HERV genes from different …

Retroelements and their impact on genome evolution and functioning

E Gogvadze, A Buzdin - Cellular and molecular life sciences, 2009 - Springer
Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial
discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes …

Molecular functions of human endogenous retroviruses in health and disease

M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …

The evolutionary volte-face of transposable elements: from harmful jum** genes to major drivers of genetic innovation

M Nicolau, N Picault, G Moissiard - Cells, 2021 - mdpi.com
Transposable elements (TEs) are self-replicating DNA elements that constitute major
fractions of eukaryote genomes. Their ability to transpose can modify the genome structure …