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Computational tools to unmask transposable elements
A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …
The developmental control of transposable elements and the evolution of higher species
M Friedli, D Trono - Annual review of cell and developmental …, 2015 - annualreviews.org
Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …
constitute essential motors of evolution through their ability to modify genomic architecture …
Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma
Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have
integrated into the genome throughout evolution. We developed a computational workflow …
integrated into the genome throughout evolution. We developed a computational workflow …
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs
Advances in vertebrate genomics have uncovered thousands of loci encoding long
noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory …
noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory …
Regulation of human MAPT gene expression
ML Caillet-Boudin, L Buée, N Sergeant… - Molecular …, 2015 - Springer
The number of known pathologies involving deregulated Tau expression/metabolism is
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …
Intronic Alus Influence Alternative Splicing
Examination of the human transcriptome reveals higher levels of RNA editing than in any
other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) …
other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) …
[HTML][HTML] Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?
Human endogenous retroviruses (HERVs) constitute 5–8% of human genomic DNA and are
replication incompetent despite expression of individual HERV genes from different …
replication incompetent despite expression of individual HERV genes from different …
Retroelements and their impact on genome evolution and functioning
E Gogvadze, A Buzdin - Cellular and molecular life sciences, 2009 - Springer
Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial
discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes …
discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes …
Molecular functions of human endogenous retroviruses in health and disease
M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …
families and occupy~ 8% of human genome. Recent success of high-throughput …
The evolutionary volte-face of transposable elements: from harmful jum** genes to major drivers of genetic innovation
Transposable elements (TEs) are self-replicating DNA elements that constitute major
fractions of eukaryote genomes. Their ability to transpose can modify the genome structure …
fractions of eukaryote genomes. Their ability to transpose can modify the genome structure …