A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations
of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Kisspeptins (Kp), products of the Kiss1 gene that act via Gpr54 to potently stimulate GnRH
secretion, operate as mediators of other regulatory signals of the gonadotropic axis. Mouse …

Since 1975, the incidence of obesity has increased to epidemic proportions, and the number
of patients with obesity has quadrupled. Obesity is a major risk factor for develo** other …

Mammalian RF-amide peptides are encoded by five different genes and act through five
different G protein-coupled receptors. RF-amide-related peptides-1 and-3, neuropeptides AF …

Different neuropeptides, all containing a common carboxy-terminal RFamide sequence,
have been characterized as ligands of the RFamide peptide receptor family. Currently, five …

Identification of RF-amide-related peptides (RFRP), as putative mammalian orthologs of the
avian gonadotropin-inhibitory hormone, has drawn considerable interest on its potential …

Abstract Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended
RFamide peptide family characterized by their common arginine (R) and amidated …

RF-amide neuropeptides, with their typical Arg-Phe-NH 2 signature at their carboxyl C-
termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout …