Quinoline–imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity

D Diaconu, V Antoci, V Mangalagiu… - Scientific Reports, 2022 - nature.com
Two new classes of hybrid quinoline–imidazole/benzimidazole derivatives (the hybrid QIBS
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …

[HTML][HTML] Green approaches for the synthesis of poly-functionalized imidazole derivatives: A comprehensive review

G Patel, DK Dewangan, N Bhakat… - Current Research in Green …, 2021 - Elsevier
The naturally occurring five-member imidazole derivatives have shown interesting biological
as well as physiochemical properties and consequently they have found several chemicals …

[HTML][HTML] Hybrid azine derivatives: a useful approach for antimicrobial therapy

D Amariucai-Mantu, V Mangalagiu, I Bejan, A Aricu… - Pharmaceutics, 2022 - mdpi.com
Nowadays, infectious diseases caused by microorganisms are a major threat to human
health, mostly because of drug resistance, multi-drug resistance and extensive-drug …

Evidence for dual site binding of nile blue a toward DNA: Spectroscopic, thermodynamic, and molecular modeling studies

M Mohammad, H Al Rasid Gazi, K Pandav… - ACS …, 2021 - ACS Publications
Binding of Nile Blue (NB) with calf thymus DNA has been studied using molecular modeling,
spectroscopic, and thermodynamic techniques. Our study revealed that NB binds to the DNA …

Bis-(Imidazole/Benzimidazole)-Pyridine Derivatives: Synthesis, Structure and Antimycobacterial Activity

V Antoci, D Cucu, G Zbancioc… - Future Medicinal …, 2020 - Taylor & Francis
Aim: Over the last decades, few significant achievements have been made in tuberculosis
(TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new …

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis …

AH Mohamed, MB Alshammari, AA Aly… - Journal of Enzyme …, 2024 - Taylor & Francis
In this article, a new series of 2-((3, 5-disubstituted-2-thioxo-imidazol-1-yl) imino)
acenaphthylen-1 (2 H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one …

Benzoquinoline derivatives: an attractive approach to newly small molecules with anticancer activity

L Oniciuc, D Amăriucăi-Mantu, D Diaconu… - International Journal of …, 2023 - mdpi.com
This study presents the synthesis, structural characterization, and in vitro evaluation of
anticancer activity of some newly benzo [f] quinoline derivatives. The synthesis is facile and …

A new approach for the synthesis of bis (3-Indolyl) pyridines via a cooperative vinylogous anomeric based oxidation using ammonium acetate as a dual reagent …

H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we introduced a new method for the synthesis of bis (3-indolyl) pyridines.
Accordingly, ammonium acetate was introduced as a dual reagent-catalyst role, for …

[HTML][HTML] A Review on the Synthesis of Fluorescent Five-and Six-Membered Ring Azaheterocycles

G Zbancioc, II Mangalagiu, C Moldoveanu - Molecules, 2022 - mdpi.com
Azaheterocycles rings with five and six members are important tools for the obtaining of
fluorescent materials and fluorescent sensors. The relevant advances in the synthesis of …

Preparation and antitumor application of N-phenylcarbazole/triphenylamine-modified fluorescent half-sandwich iridium (III) Schiff base complexes

L Wang, C Huang, F Hu, W Cui, Y Li, J Li, J Zong… - Dalton …, 2021 - pubs.rsc.org
Four N-phenylcarbazole/triphenylamine-appended half-sandwich iridium (III)
salicylaldehyde Schiff base complexes ([(η5-Cpx) Ir (O^ N) Cl]) were prepared and …