Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Review of the current trends in clinical trials involving induced pluripotent stem cells

JY Kim, Y Nam, YA Rim, JH Ju - Stem cell reviews and reports, 2022 - Springer
In 2006, the induced pluripotent stem cell (iPSC) was presented to the world, paving the way
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …

The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy

D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

Mesenchymal stromal cells for the treatment of graft versus host disease

K Kelly, JEJ Rasko - Frontiers in immunology, 2021 - frontiersin.org
Graft versus host disease (GvHD) is a life-threating complication of allogeneic hematopoietic
stem cell transplantation, which is initially treated with high dose corticosteroids …

Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review

Y Li, J Hao, Z Hu, YG Yang, Q Zhou, L Sun… - Stem Cell Research & …, 2022 - Springer
Background Graft-versus-host disease (GVHD) is a common fatal complication of
hematopoietic stem cell transplantation (HSCT), where steroids are used as a treatment …

Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

G Copp, KP Robb, S Viswanathan - Cellular & Molecular Immunology, 2023 - nature.com
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

Mesenchymal stem cells as a bio organ for treatment of female infertility

S Esfandyari, RM Chugh, H Park, E Hobeika, M Ulin… - Cells, 2020 - mdpi.com
Female infertility is a global medical condition that can be caused by various disorders of the
reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome …