Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

Despite their simplicity, viruses exhibit certain types of social interactions. Situations in which
a given virus achieves higher fitness in combination with other members of the viral …

Transmission bottlenecks limit the spread of novel mutations and reduce the efficiency of
selection along a transmission chain. While increased force of infection, receptor binding, or …

Segmentation of viral genomes into multiple RNAs creates the potential for replication of
incomplete viral genomes (IVGs). Here we use a single-cell approach to quantify influenza A …

Interactions between viruses during coinfections can influence viral fitness and population
diversity, as seen in the generation of reassortant pandemic influenza A virus (IAV) strains …

Influenza A virus (IAV) genetic exchange through reassortment has the potential to
accelerate viral evolution and has played a critical role in the generation of multiple …

Within the human respiratory tract (HRT), virus diffuses through the periciliary fluid (PCF)
bathing the epithelium. But virus also undergoes advection: as the mucus layer sitting atop …

SARS-CoV-2 is a human pathogen that causes infection in both the upper respiratory tract
(URT) and the lower respiratory tract (LRT). The viral kinetics of SARS-CoV-2 infection and …

Replicating recombinant vector vaccines consist of a fully competent viral vector backbone
engineered to express an antigen from a foreign transgene. From the perspective of viral …

The success of many viruses depends upon cooperative interactions between viral
genomes. However, whenever cooperation occurs, there is the potential for 'cheats' to …